The research behind Remrise

We selected every Remrise ingredient for specific sleep-promoting, health-enhancing benefits. In tandem, the Chinese and Western herbs in our formulas are proven effective for sleep — without side effects.  

 

The best Western ingredients

The Western herbs, minerals, and amino acids in your formula are proven to increase your quality of sleep over time.

5-HTP

What it is: 5-Hydroxytryptophan is a crucial amino acid that is naturally occurring in the body and vital to the production of serotonin. Low levels of serotonin correlate to symptoms of anxiety, disrupted sleep, weight gain, and dysregulated mood.  

Why it’s in our formulas: 5HTP helps to produce melatonin (one of the hormones responsible for regulating sleep cycles)  naturally in the brain. Research has shown that Incorporating this amino can be effective in helping you falling asleep faster and staying asleep. 

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GABA

What it is: Gamma-Aminobutyric Acid, often called by its acronym “GABA”, is an amino acid that is produced by the brain. Its primary functions are as an inhibitory neurotransmitter, to block impulses between nerve cells and in doing so, promote mental and muscular relaxation. 

Why it’s in our formulas: It works in the brain by interacting with the neuron receptors, which become less likely to release excitatory neurotransmitters. The result of which include anxiety relief, improved mood and a list of other benefits.  As a supplement this amino acid is often used for sleep, reducing blood pressure, promoting muscle growth, pain relief, burning fat and more. 

Relatively new to the supplement scene, there has not yet been a tremendous amount of research on its efficacy as a supplement relating directly to sleep. But the small body of research is showing promising signs of its benefits.

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Phosphatidylserine

What it is: This fatty substance, known as a phospholipid, is a key component to the cell membrane.  It’s responsible for cellular building blocks of the brain, produced by the body and also derived from food products like soy, mackerel, tuna, and chicken.

Phosphatidylserine is comprised of fatty acids and amino acids, often associated with optimal brain health, memory and cognition. Traditionally, supplementing the diet with this substance was aimed to prevent or reduce Alzheimer’s disease. 

Why it’s in our formulas: Studies indicate that poor sleep is influenced by unregulated cortisol production and similarly, acute sleep loss impairs functional cortisol. A study focusing on sleep health and development of Alzheimer’s disease, indicated that phoshphatidylserine for a period of 12 weeks reduced cortisol concentrations in the body, with further benefit by regulating the circadian rhythm of salivary cortisol. 

Due to its effects on cortisol regulation in the body, phosphatidylserine is effective in reducing hyperactive cortisol function at night, thereby reducing waking in the middle of the night and related symptoms that cause sleep disruption.

 

Magnesium

 

What it is: Magnesium is one of seven essential minerals critical to the body. It plays a central role in maintaining your metabolic health.  In food, magnesium can be found in seeds, nuts, dark leafy greens, whole grains and a bunch of other food sources. 

Your body does not produce magnesium, it has to be ingested. About half of Americans aren’t getting enough magnesium in their diet. 

Why it’s in our formulas: Aside from its role regulating and facilitating a long list of functions, there is a growing body of research demonstrating magnesium’s efficacy in treating sleep. 

Remrise uses Magnesium Glycinate, which plays a key role in affecting the brain’s GABA activity. Additionally, studies have linked magnesium to stress reduction. While this body of research grows in rigor, the research shines favorably on its ability to alleviate anxiety.

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Valerian root

 

What it is: Valerian is a flowering plant found throughout Europe and Asia. The use of its root for medicinal purposes goes back thousands of years. Often referred to as “nature’s Valium”, it has been shown to reduce anxiety, a major cause of sleeplessness. 

Why it’s in our formulas: Several studies point toward its ability to modulate GABA transmission in the brain as a potential mechanism of action. There is a growing body of research into valerian root’s efficacy on healthy patients showing strong results for improving sleep

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L-tryptophan

What it is: L-tryptophan is an essential amino acid that is crucial to many metabolic functions and plays an important role in mood, behavior and cognition. It is one of the three precursors to the production of melatonin in the brain, essential for healthy sleep. 

Why it’s in our formulas: It has been used in a variety of research settings and clinical trials safely for over 30 years. Unlike many medications it does not hinder waking up in the morning or cognitive functioning. Research shows that L-tryptophan reduces the time it takes to fall asleep and improves stage IV sleep.

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L-Theanine

 What it is: This amino acid was first discovered by Japanease tea scientists who isolated the substance in tea leaves. Further research uncovered this amino’s ability to promote relaxation by increasing brain chemicals, like seratonin and dopamine. Most importantly, alpha waves, which are present in deep REM sleep are triggered by L-theanine. 

Why it’s in our formulas: In addition to optimizing rest and relaxation, L-theanine will enhance meditation, creativity, and focus, via these alpha wave receptors. 

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Hops flower

 

 What it is: Hops is considered a mild sedative that reduces nervous tension and stress.  As a relaxant it reduces overall stress in the body, cools it down when overheated, and decreases inflammation. Classically, it was used as a digestive aid due to its bitter quality, which addresses abdominal discomfort, bloating and gas. 

Why it’s in our formulas: It’s a well known remedy for sleep, as it acts on the neurotransmitter GABA to increase its activity, subsequently decreasing anxiety and calming the mind. In one study, hops flower was shown to be more effective in decreasing the time it takes to fall asleep when blended with Valerian Root. In the study the blended Hops and Valerian performed better than placebo or the individual hops or valerian. 

 

Calcium Citrate

 

What it is: Calcium is a crucial mineral for the body, but unfortunately our bodies don’t produce it. Most people know of its importance to bone health, but it also enables our muscles to contract and our hearts to beat. 

If we don’t get enough calcium for the vital role it plays in our bodies, then our bodies body takes it from our bones and over time this can cause them to weaken and break more easily, especially as we age. 

Why it’s in our formulas: Calcium has a direct relationship with our sleep cycles. It helps the brain use tryptophan to produce melatonin to fall asleep. This is why some studies have found that sufficient calcium intake has been associated with decreased difficulty in falling asleep

Studies have also shown that calcium levels in the body are higher during our deepest parts of sleep, thus low levels of calcium can contribute to sleep disturbance, waking easily and poor quality of sleep.

Unlike calcium carbonate, which needs to be taken with food for absorption purpose, calcium citrate can be absorbed on an empty stomach, making it ideal for option for sleep supplementation.

 

Passion Flower

What it is: Native to the Americas, Passion flower has been used by Native Americans to treat several types of conditions for thousands of years. There are over 500 types of passionflower in the world. Only certain species have medicinal properties. Passiflora incarnata is the type used to treat both insomnia and anxiety. 

Why it’s in our formulas: There is evidence that passionflower may alleviate the symptoms of anxiety disorder, which can commonly cause sleep disturbances.

Passionflower targets the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which is responsible for inhibiting excitation that leads to restlessness or nervous tension. Through its anti-anxiety and sedative effects, it also gently improves one’s mood and quiets the mind.

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Centuries-old Chinese herbs

The Chinese herbs in Remrise have been used for thousands of years to promote healthy sleep and enhance overall wellness.

Spine Date Seed (Suan Zao Ren)

What it is: Suan Zao Ren and the zizyphus species of plants have been used medicinally and as a source of food for thousands of years. Suan Zao Ren is considered one of the most effective Chinese botanicals to promote sleep. 

Its botanical properties sedate and calm the spirit to lessen anxiety and promote rest.

Why it’s in our formulas: Studies have confirmed some of the traditional reasons Suan Zao Ren is a therapeutic herb correlate to its sedative effects.

Studies have also shown its efficacy in reducing anxiety and improving sleep quality.

 

Anemarrhena Rhizome (Zhi Mu)

What it is: Zhi Mu is effective in cooling the body, acting as a deeply nourishing herb in traditional Chinese medicine. 

Why it’s in our formulas: Research suggests that Zhi Mu has the potential to enhance and protect memory impairment by improving the speed of the neurotransmitter acetylcholine (ACh) and the density of its receptors. 

In relation to sleep, acetylcholine plays a key role in REM sleep functions. Therefore the mechanism of action of Zhi Mu indirectly optimizes sleep-wake cycles for optimal sleep.

 

Polygala (Yuan Zhi)

Polygala for sleep

What is it?: Polygala is a perennial herb found both in China as well as western and central parts of the US. 

Aside from its sleep promoting benefits, Polygala has also been shown to enhance cognitive function, it’s an antioxidant and adaptogen. That might sound like a lot of buzzwords in a row but Polygala has also been well studied.

Why it’s in our formula: In Chinese medicine, Yuan Zhi focuses largely on mental-emotional wellness in relation to physical health and day-to-day wellbeing.

Typically thought to be most effective for pent-up emotions and/or excessive brooding. Related issues may include anxiety, sleep problems, and restlessness.  

Studies have shown its capacity to increase total sleep time. Another study showed that it also  prolonged NREM stages.  

 

Schizandra (Wu Wei Zi)

Schisandra for sleep

What is it? Schizandra (also called magnolia berry, or five-flavor-fruit) is native to the forests of Northern China and the Russian Far East.

It is a deciduous woody vine that imparts hardy bunches of red berries that are often eaten, as well as used to make herbal medicine.  

Schizandra has been shown to improve sleep quality, sleep duration, and shorten sleep latency.  Further, studies suggest meaningful sedative effect on sleep. 

 

Angelica Root (Dang Gui)

Angelica Root for sleep

What is it? Angelica root is an integral Chinese herb used for a range of health purposes from improving sleep to help balance hormones, support health, and even clear skin complexion. 

Why it’s in our formula: Aside from its calming effects,  Angelica Root has shown in studies to have many more benefits including deeper slow wave sleep. It has even been shown to lengthen slow wave sleep stages, prolonging sleep duration.

Magnolia Bark (Hou Po)

Hou Po for sleep

What is it? Magnolia bark comes from the magnolia tree where it grows in numerous provinces in China. Traditionally, it is used to aid in digestive discomfort, alleviating bloating, stomachaches, and supports healthy digestion.

Modern research indicates that the active ingredient in hou po is magnolol, which induces sleep by accessing the GABA pathway.

Why it’s in our formula: Hou Po has been shown to promote sleep via the GABA receptors, shortening sleep latency and increase the number of NREM and REM sleep episodes.

In addition to its sleep benefits, Hou Po has been shown to have noteworthy health benefits.

 

Reishi (Ling Zhi)

What is it? Reishi is a very popular mushroom for sleep. Its popularity stems from its multiple health benefits. It reduces the effects of fatigue, improves immune health and sleep outcomes and the list goes on. 

Grown in parts of Asia that are hot and humid, this large mushroom can be eaten fresh, as a powder or in various extract forms.

Why it’s in our formula: Reishi has been demonstrated to improve immune health. While its mode of action is unclear, Reishi has been demonstrated to be an effective natural sleep aid efficacy for improving sleep.